Quality Structural Engineering Services from Drawings to 3D Models Visit Us: buildinginformationmodelling… #structure #structuralengineering #structuralmodeling #structuraldrafting #structuraldesign #buildingstructure #structuralengineers

Today I started developing the slab tool for #StructureTools #structuralengineering #structuralmodeling #grillage #spaceframes #structuralanalysis @FreeCADNews

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A Unified Framework for TCR-pMHC Structural Model Assessment 1. This study introduces a novel framework for assessing the quality of TCR-pMHC structural models without requiring experimental reference structures. The framework leverages multiple modeling and interface confidence metrics integrated into explainable random forest classifiers, trained on 1160 models of 232 experimentally determined PDB TCR-pMHC class I complexes. This approach reliably distinguishes between low-, acceptable-, medium-, and high-quality models, outperforming traditional metric thresholds. 2. The study benchmarks five state-of-the-art protein modeling tools (AlphaFold3, Boltz-2, Chai-1, tFold-TCR, and TCRmodel2) on a set of 20 experimentally resolved TCR-pMHC class I structures. AlphaFold3 demonstrated superior performance, with 90% of models classified as acceptable or better, including 20% high-quality models. This highlights the potential of AlphaFold3 for generating reliable TCR-pMHC models. 3. The researchers expanded the structural landscape of TCR-pMHC class I complexes by generating a large synthetic dataset using AlphaFold3. This dataset includes 33,820 unique complexes (169,100 models) from VDJdb-annotated sequences, representing a >70-fold increase in available structures. This expansion provides a valuable resource for downstream applications such as epitope mapping and predictive modeling. 4. The quality tier framework was applied to filter and validate TCR-pMHC interactions in sequence databases like VDJdb. Higher-quality models were significantly enriched for biologically validated interactions, with high-quality models achieving the highest enrichment. This suggests that model quality can be used as a filtering criterion to identify false positives in sequence databases. 5. The study also demonstrates that high-quality structural models enhance the predictive performance of TCR-pMHC pairing algorithms. Using the IMMREP23 dataset, the researchers showed that higher-quality models are enriched for positive TCR-pMHC pairs and improve the accuracy of pairing predictions. This highlights the potential of the framework for improving TCR-based immunotherapies. 📜Paper: biorxiv.org/content/10.1101/… #TCR #pMHC #StructuralModeling #AlphaFold3 #Immunology #Bioinformatics

Fitness Aligned Structural Modeling Enables Scalable Virtual Screening with AuroBind 1. AuroBind is a novel virtual screening framework that integrates atomic-level structural modeling with binding fitness prediction, achieving state-of-the-art performance in identifying potential drug candidates. This framework fine-tunes a custom structural model on million-scale chemogenomic data, enabling high-throughput screening across ultra-large compound libraries. 2. AuroBind outperforms existing methods in both structural accuracy and functional prediction. It achieves experimental hit rates of 7–69% across ten diverse protein targets, with some compounds reaching sub-nanomolar to picomolar potency. This demonstrates its ability to identify potent ligands for a wide range of therapeutic targets. 3. The framework incorporates a two-stage training strategy: first, it is trained on a curated dataset of protein-ligand complexes to ensure structural accuracy, and then fine-tuned on chemogenomic data to align with binding fitness. This dual approach ensures both high structural fidelity and functional relevance. 4. AuroBind introduces a lightweight student model, AuroFast, which accelerates screening by 100,000-fold without sacrificing accuracy. This allows for the rapid evaluation of millions of compounds, making it feasible to screen large chemical libraries in a matter of hours. 5. In prospective screening campaigns, AuroBind successfully identified active compounds for orphan GPCRs, including GPR151 and GPR160, where no known binders or crystal structures were available. This highlights its potential for discovering novel ligands for previously intractable targets. 6. The study validates AuroBind’s performance through wet-lab experiments, demonstrating its ability to generalize across diverse protein families and identify high-potency hits. This underscores its practical utility in real-world drug discovery efforts. @Edgar_Zheng 📜Paper: arxiv.org/abs/2508.02137 #AuroBind #VirtualScreening #DrugDiscovery #StructuralModeling #BindingFitness #GPCRs #HighThroughputScreening

I am pleased to announce that the #StructureTools workbench is now available for installation in the @FreeCADNews Addon Manager. #structuralengineering #structuralmodeling #spaceframes #structuralanalysis #AEC #BIM #StructureAnalysis #CivilEngineering #Structural #engine

Parametric model of metal beam joints using splints, used both to determine the stiffness of the connection through finite element analysis and for construction detailing. @FreeCADNews #structuralmodeling #structuralanalysis #AEC #StructureAnalysis #CivilEngineering #Structural

Commercial project made with the StructureTools bench in @FreeCADNews , mezzanine with a free span of 10 m. #structuralengineering #structuralmodeling #spaceframes #structuralanalysis #AEC #BIM #StructureAnalysis #FreeCAD #CivilEngineering #Structural #engine #StructureTools

We now also have a YouTube channel, all demonstrations and video tutorials about the tools will be posted there, subscribe so you don't miss anything. youtube.com/@structuretools #StructuralAnalysis, #FiniteElementAnalysis, #StressAnalysis, #StructuralModeling, #StructuralSimulation

Unveiling the non canonical activity of E2: a new study from De Cesare lab ppu.mrc.ac.uk/news/unveiling… #Research #Ubiquitin #E2enzymes #PostTranslationalModification #Discovery #MassSpectrometry #StructuralModeling #UbiquitinSignaling

Look inside Structural Econometric Modeling in Industrial Organization and Quantitative Marketing by Ali Hortaçsu & Joonhwi Joo for a concise & rigorous introduction to widely used approaches in structural econometric modeling. hubs.ly/Q026_N140 #StructuralModeling

The December issue of @JMDiagn is now live! Full issue: jmdjournal.org/issue/S1525-1… #ovariancancer #beadcapture #structuralmodeling #isoform

#structuralmodeling #incose_org #isss #ieee #systemengineering researchgate.net/publication… Another report on the connection between natural language and mathematics Begins to establish a clear foundation for translation. Expands areas of exploration

researchgate.net/publication… #structuralmodeling #incose #incose_org #isss #ieee #systemengineering This report evaluates the Interconnection Matrix form and processes. System structuring relationship attributes (global and local) are evaluated.

Will you be attending next week's Fabtech Conference? Make sure you make time to visit booth #B8776 and have a chat with Tekla's software experts! #differentbutbetter #fabtech #fabrication #bim #3dmodeling #structuralmodeling #digitalconstruction #tekla #trimble

Rational #structuralmodeling supports real systems science principles and laws. #incose #incose_org #systemengineering #ieee #isss researchgate.net/publication… Clear context and process definition supports rational structural modeling and analysis.

#structuralmodeling #incose_org #isss #ieee #systemengineering researchgate.net/publication… Important report on the connection between natural language and mathematics Begins to establish a clear foundation for translation.

👉 Catch up with the latest version on ANSYS 2022 R1 release update session on Structural mechanics and LS Dyna. Link: zcu.io/ft3d #Ansys #cadfem #simulation #structuralengineering #structuralmodeling #structuraldesign #mechanics #lsdyna #ansysforming #additive

Our new tool makes modeling of any stair shapes easy and straightforward. See how it works and try it yourself! 👉 tek.la/204 #teklastructures #BIM #3dmodeling #stairs #structuralmodeling #precastconcrete #digitalconstruction #tekla #trimble #differentbutbetter