Super excited to share that ENGRAM is out today! ENGRAM cells are programmed to write their histories into the genome, recording the intensity, duration, and order of biological events simultaneously. nature.com/articles/s41586-0…

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

New preprint! @JShendure @CXchengxiangQIU Can we learn regulatory grammars of human cell types we'll never be able to profile - by training on mouse development and transferring across 241 mammalian genomes?biorxiv.org/content/10.64898…

Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s41586-0…

absolutely excited to see @CXchengxiangQIU starting his own lab at Dartmouth! Great adventure awaits!

The Wilkinson Lab is open for science! @MSKCancerCenter 🧬We'll be finding funky new RNA biology, mainly by looking at reverse transcriptases (i.e. the Best Enzymes In The World)🧬

Super excited re: first Shendure/Baker Lab collaboration & preprint on a multiplex sequencing-based strategy for screening de novo proteome editors in mammalian cells. Kudos to brilliant Chase Suiter & @Green_Ahn @UWproteindesign on the work! Preprint: biorxiv.org/content/10.1101/…

We are pleased to share our new preprint: “De novo design of RNA and nucleoprotein complexes”. This work extends the principles of de novo protein design to RNA and DNA, enabling the generative design of complex multi-polymer structures! (1/6) doi.org/10.1101/2025.10.01.6…

pH gradients are central to physiology, from vesicle acidification to the acidic tumor microenvironment. But how do we program proteins to respond to pH? In our new preprint biorxiv.org/content/10.1101/…, we developed computational methods to rationally design pH-sensitive binders. 🧵

We sought to make proteins both potent and FAST. We used #proteindesign to design precise control over protein interaction lifetimes, enabling us to construct rapid-response circuits, biosensors, and switchable cytokines. Now published @Nature! Links to paper and tutorial below.

Phosphorylation on tyrosines control key pathways in immunity, cancer, and metabolism. For the first time, we can now design proteins that specifically recognize individual phosphotyrosines, even in disordered regions. (1/8) Preprint: biorxiv.org/content/10.1101/…

Congrats @JingchuanLuo. Really novel way to study localized translation.

Beautiful work! congrats @yodai_takei !

Congrats @JONA. such beautiful paper

Congrats on this beautiful paper! @sudpinglay

Excited to finally share Perceptein, a PERCEPtron made of proTEINs: science.org/doi/10.1126/scie…

Finally out in @ScienceMagazine! Utilizing the cost-effective EasySci to profile 21 million single-cell transcriptomes across five life stages and diverse sexes/genotypes, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows. We also demonstrate how highly scalable single-cell genomics enables "Functional Cell-omics" to unravel Cell Regulatory Networks at the whole-organism scale. Congratulations to the incredible Zehao Zhang (@Tommyz626) from our lab @RockefellerUniv for leading this work! science.org/doi/10.1126/scie…