Associate Professor @UWBiochem studying lipid signaling and regulation | HHMI FHS | opinions are my own and do not reflect those of my employer
Joined November 2018
- Tweets 2,267
- Following 1,531
- Followers 3,043
- Likes 21,549
191 Photos and videos
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15 May 2025
Thrilled to have our story on the regulation of lysosomal lipids out in @Cell_Metabolism! The work was led by two outstanding grad students @_JessDavidson and Raghav Jain probing mechanistic control of energy expenditure @HHMINEWS @UWBiochem
14 May 2025
New! Online now: Hepatic lipid remodeling in cold exposure uncovers direct regulation of bis(monoacylglycero)phosphate lipids by phospholipase A2 group XV dlvr.it/TKmVgH
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Our latest study out in @MolecularCell explores how and why MHC class I is aberrantly targeted for degradation via the autophagy-lysosome pathway in pancreatic cancer. Congrats to postdoc extraordinaire @marineberquez for leading this study! @UCSFAnatomy @UCSFCancer
May 29
Online Now: A multi-subunit autophagic capture complex facilitates degradation of ER-stalled MHC class I in pancreatic cancer dlvr.it/TSn7r3
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Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq
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In the W-S lab's first preprint, we describe how genomic language models know something about RNA thermodynamics. Though we think this is cool, things get tricky!
A growing practice for interpreting LMs is to perturb input tokens, often called "Categorical Jacobian": 👇
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Join us for Isabella James's Ph.D. thesis defense on June 19. Her research in the @JudithSimcox Lab focused on ceramides, a class of lipids, investigating their synthesis and how they move among tissues. Learn more: ipib.wisc.edu/2026/05/29/ipi…
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May 29
In a paper just published in @sciencemagazine, we teamed up with @teichlab to construct the most detailed atlas to date of hormone production and action in humans at cellular resolution. (1/8)
Link: science.org/doi/10.1126/scie…
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May 27
New publication from our group: what happens inside human endometrial tumors during a ketogenic diet?
We analyzed paired tumor biopsies before and after a very low-carbohydrate intervention in women with endometrial cancer 🧵
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May 24
Excited to share the first manuscript from our lab! Here we identified a shared enzymatic mechanism linking N-acetylated β-amino acids to energy balance regulation @jbiolchem. Congratulations to our first PhD student, Ruida Li, from @CMB_UWMadison, for leading this work. Grateful for the tremendous support from @JudithSimcox @UWBiochem @longlabstanford @ssiipei
jbc.org/article/S0021-9258(2…
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May 19
Happy to have contributed to this preprint with Fangzhu Zhao and @realJimWells! LRP8-targeted bispecific antibody degraders degrade the selenium uptake receptor LRP8, reduce GPX4 / selenoproteins, and sensitize cancer cells to ferroptosis.
biorxiv.org/content/10.64898…
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May 7
Two for Thursday: We want to highlight another fantastic collaboration, this time with William Oldham's lab at Brown University and our @N8Krah, demonstrating that MCT4 is a druggable target in pulmonary fibrosis. Check it out here: science.org/doi/10.1126/scit… @UofUHematology @huntsmancancer
Congrats to everyone involved!
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Apr 29
Dearest gentle reader, we are delighted to announce a new story from our lab published in @Nature describing how a meal's systemic metabolic changes are interpreted by your immune system to enhance adaptive immunity. A thread 1/ nature.com/articles/s41586-0…
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The Booker Lab at the University of Pennsylvania, in Philadelphia, and HHMI is searching for a lab manager. If interested, please apply at the HHMI link below.hhmi.wd1.myworkdayjobs.com/e…
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Apr 22
For 40 years, we’ve known how UCP1 drives thermogenesis—but how UCP1-independent pathways are activated remained unknown. Thrilled to share our @Nature paper, led by Faiz Hussain, uncovering this mechanism:
nature.com/articles/s41586-0…
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📢🎉@hhmi_science competition for the next cohorts of #HannaGray Fellows and #FreemanHrabowski Scholars opening 11/3/2026. Senior postdocs and faculty within 7 years of appointment. Up to $10M over 10 yrs, salary & benefits. Spread the word and consider applying! bit.ly/4vhC0LA
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Apr 15
I am very happy to share that our paper is now published in @Nature 😊
Cell-type-targeted mitochondrial transplantation rescues cell degeneration.
nature.com/articles/s41586-0…
@IOB_ch (1/6)
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Updated preprint! Here, we identify an SREBP-dependent fatty acid sensing metabolic switch in Drosophila, enabling dramatic metabolic rewiring within adipose tissue that boosts carbohydrate metabolism in the absence of fat.
Read more here:
biorxiv.org/content/10.1101/…
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Apr 10
New publication from the lab, led by the talented graduate student @ankurkumar110 , demonstrating that reduced plasmalogen ether lipid biosynthesis may contribute to age-dependent impairments of mitochondrial morphology and membrane dynamics. authors.elsevier.com/a/1mrba…
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Apr 9
Interested in aging and rejuvenation?
We have a new Research Assistant position to understand aging at the cellular level!!
Come join our team!!! 😎
careersearch.stanford.edu/jo…
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Our Human Multiomic Development Atlas paper is out in Nature today! A heart-felt "thank you" to all co-authors for their tireless work on this complex yet exciting project! Congrats all! nature.com/articles/s41586-0…
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📣 Abstracts are open registration is live!
Join us at the 11th Annual Chicago Mass Spec Day 2026
📅 July 15 | 📍 University of Illinois Chicago
🎓 Posters • Talks • Networking
🔗 chicagomassspecday.weebly.co…
#2026CMSD #Omics #TeamMassSpec
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Another hard-won project from the lab. We've been trying to understand how proteins get into the mitochondrial outer membrane for almost a decade, and hopefully we're finally getting closer. The structure, evolution, and mechanism of MTCH2: biorxiv.org/content/10.64898…
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