Interactome mapping has been stuck at a few hundred baits over months. HIP-MS changes the regime: ~10,000 pulldowns/week at 500 samples/day, fully automated. A new era for interactomics — and a precursor to high-throughput proteomics writ large. doi.org/10.64898/2026.06.03.…

1/5 Cell identity is written in the proteome, not in the DNA, and not always in the RNA. Out on bioRxiv today: The first cell type-resolved, MS-based proteomic atlas of the human body. biorxiv.org/content/10.64898…

Going from the discovery of epigenetic silencing of CTCF insulators nature.com/articles/s41586-0… to aberrant E-P looping cell.com/molecular-cell/full… to a successful clinical trial nature.com/articles/s41591-0… all from Brad Bernstein's lab

10/ Remarkable. We are still way far from trully decyphering regulatory logic. For now, we are working with sophisticated, yet surprisingly easy-to-break, dictionaries.

Could the folding of synthetic gene circuits in 3D shape how genes are expressed? Today @ScienceMagazine we report on the role of gene syntax in shaping feedback between transcriptional activity and genome folding for advanced circuit design🧵 (1/n)

Just out: our forward-looking essay on mRNA “delivery cells”—engineered cells that could locally manufacture mRNA at disease sites within the body and transfer it to target cells in extracellular vesicles.

Can we control cells by forcing TFs to collaborate? Interested? Read our preprint! An awesome collaboration with @cgersbach, @christian_mcam, @IGVFConsortium, led by @Rachel_E_Savage: biorxiv.org/content/10.64898… 🧵

Very cool finding. Depending on how you look at it, is our genome remarkably robust or remarkably fragile? 🤔

What if a small molecule could activate a transcription factor program in one cell type and destroy the same pathway in another? In our new preprint, we describe one such story on bifunctional molecules that toggle between transactivation and repression.

Today we're launching Latent-Y: the world's first autonomous agent for drug design, lab-validated end to end. Give it a research goal. Latent-Y reasons, designs, iterates, and delivers lab-ready antibodies, autonomously or collaboratively, with the biological reasoning of a PhD protein design expert. Technical report: tinyurl.com/latent-y-techrep… Blog post: latentlabs.com/latent-y Apply for access: platform.latentlabs.com

Unstructured transcription factor interactions enable emergent specificity | @ScienceMagazine science.org/doi/10.1126/scie…

Are the enhancer regions that control the expression of lineage genes established from early embryonic stages or do they gain their transcriptional potential along differentiation? Today in @CellGenomics we address this question: tiny.cc/r5j0101 1/15🧵

A few days late in sharing, but but thrilled to share that my postdoctoral work on #3Dgenome and #CellularMemory is now published in @NatureGenet: nature.com/articles/s41588-0…

New from us in @CellGenomics: Using FFPE-compatible Hi-C to detect oncogenic rearrangements genome-wide in routine lymphoid cancer biopsies. Congrats to first author pathologist-scientist Jamin Wu, co-senior author Matija Snuderl @NYUGSOM_Path, and @ArimaGenomics.

I can imagine a future where it might be a novelty, and a pleasure, to work exclusively with humans

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The @ENCODE_NIH Phase 4 Registry of candidate cis regulatory elements (ccREs) (2.37 million human and 967,000 mouse cCREs) is officially out screen.wenglab.org/ nature.com/articles/s41586-0… Congrats to @MooreJillE @ZhipingWeng & everyone else. Lots more incoming ...

Excited to share our new study published online today @CD_AACR. Beyond mutagenesis, we show that LINE-1 locus-specific transcription reshapes 3D genome architecture to control cancer gene expression @JianXuLab @StJudeResearch aacrjournals.org/cancerdisco…

A New Year, a new paper out on Jan 1 in @ScienceMagazine ! Congratulations to @SiddhantUJain and all our co-authors and collaborators! This study answers a longstanding question in our field regarding recruitment of chromatin regulatory machinery and provides a powerful new framework for development of precision medicines in #cancer and beyond! @kadochlab @alex2110x @hhmi_science @DanaFarberNews @DanaFarber science.org/doi/10.1126/scie… #generegulation #chromatin #cancer #therapeutics #basicscience #BAFcomplex #mSWISNF #chromatinremodeling

Excited to share our preclinical study showing excellent response to venetoclax gilteritinib in BCL11B-activated lineage ambiguous leukemia, co-led with @IlariaIacobucc1: doi.org/10.1182/blood.202502…. Funded by @BloodCancerUtd and @NIH. @StJudeResearch @BloodPortfolio @CMullighan