@_themovingvan_ profile picture
Trevor Van Eeuwen @_themovingvan_

Anderson Cancer Fellow in @RoutLab_RU | Love a good mural | Here for the memes.

Joined June 2009
  • Tweets 1,458
  • Following 284
  • Followers 249
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Trevor Van Eeuwen@_themovingvan_
14 Dec 2023
So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature nature.com/articles/s41586-0…
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Yi-Wei Chang@yiweichang
15 May 2025
Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals. science.org/doi/10.1126/scie…

Molecular basis of influenza ribonucleoprotein complex assembly and processive RNA synthesis

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–elec...

science.org
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Yi-Wei Chang@yiweichang
23 Jan 2025
Thrilled to share our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller (@PennMedicine,@BMBGGUPENN,@BB_UPenn), now in @CellCellPress! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️ authors.elsevier.com/c/1kUW9…

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Congrats @TriggerLoop and @PennMurakamiLab on transcription start site scanning and contributions from everyone’s favorite general transcription factor TFIIH academic.oup.com/nar/article…

Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3

Abstract. RNA polymerase II (pol II) initiates transcription from transcription start sites (TSSs) located ∼30–35 bp downstream of the TATA box in metazoan

academic.oup.com
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Jason Kaelber@Kaelberviridae
28 Aug 2024
We tracked a pandemic decimating beetle colonies and used cryoEM for sequencing-free discovery of the new virus that caused it. This virus is crazy; parvoviruses aren't supposed to have such structured protein-DNA interactions. We fulfilled all 4 of Koch's postulates for etiology
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Evan O’Brien@evan_s_obrien
21 Aug 2024
Can't believe I get to say this, BUT...just started as an assistant professor @BiophysicsJHMed @HopkinsMedicine! So excited to work with all of my new colleagues in the Hopkins Biophysics community!
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Congrats @buildmodels on your new addition!
Arthur Zalevsky@ArthurZalevsky
14 Aug 2024
It's finally happened. Integrative structures are now in the PDB archive! wwpdb.org/news/news?year=202… Check out the structures on the PDB-Dev website pdb-dev.wwpdb.org/ and in the main archive files.wwpdb.org/pub/pdb_ihm/ Congrats to the team, especially @brinda_vallat!
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Digvijay Singh@dgvjayS
12 Aug 2024
Our work on the architecture and model of the #NuclearBasket is now out @CellCellPress. cell.com/cell/pdf/S0092-8674….  @HHMINews, @IntActOme #NPC #teamtomo A short tweetorial follows
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Neelesh Soni@neeleshsoni03
9 Aug 2024
From preprint to journal. Our nuclear gatekeepers have successfully unlocked the gates to Cell (Journal) cell.com/action/showPdf?pii=… #NPC #integrativemodeling Congrats to team @dgvjayS @JoshHutchings94 @ig_ech @RoutLab_RU @salilab_ucsf @TheVillaLab Animation youtube.com/watch?v=LiKdFIxr…
Neelesh Soni@neeleshsoni03
29 Mar 2024
Tiny gatekeepers of our nucleus decide what gets in and out. Follow our study on Yeast and Mammalian NPC baskets and unravel the molecular structure of these cellular bouncers! Don't miss the side-by-side comparison in the video. #IntegrativeModeling biorxiv.org/content/10.1101/…
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Waggoner Lab@LabWaggoner
15 Jul 2024
Competition between two HUSH complexes orchestrates the immune response to retroelement invasion @MolecularCell cell.com/molecular-cell/full…
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Yong Xiong Lab@Xiongosome
11 Jul 2024
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells! biorxiv.org/cgi/content/shor…
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So incredibly grateful to be part of this amazing team and happy to share this cool structure with the world! sciencedirect.com/science/ar…

Hee Jong Kim@heejjongkim
3 Jul 2024
Humbly sharing my first author paper, Structure of Hir histone chaperone complex. (yeast version of HIRA) Collaborative work from Murakami Lab, @MarmorsteinLab, @GarciaLabMS, @TriggerLoop and thanks for @bradyajohnston's MolecularNode. sciencedirect.com/science/ar… open access.
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Vivien Horvath@VivienHorvath8
4 Jun 2024
I am thrilled to see my first postdoc paper published in @NatureSMB! 🌟🧠🧬 “Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease” nature.com/articles/s41594-0… 1/n 🧵
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bioRxiv Biophysics@biorxiv_biophys
13 May 2024
Disulfide constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM biorxiv.org/cgi/content/shor… #biorxiv_biophys
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Tim Kenny@TimCKenny
1 May 2024
Following up our work describing FLVCR1 as a high affinity choline transporter @KivancBirsoy @ArtemAKhan, excited to share our recent work in close collaboration with @Yeeun_Jecy_Son @HiteLabMSKCC describing the structure and mechanism of action of FLVCR1! nature.com/articles/s41586-0…

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Neelesh Soni@neeleshsoni03
29 Mar 2024
Tiny gatekeepers of our nucleus decide what gets in and out. Follow our study on Yeast and Mammalian NPC baskets and unravel the molecular structure of these cellular bouncers! Don't miss the side-by-side comparison in the video. #IntegrativeModeling biorxiv.org/content/10.1101/…
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Andrej Sali lab@salilab_ucsf
29 Mar 2024
Proud to share the result of an amazing collaboration with Javi Fernandez-Martinez, @RoutLab_RU , and @TheVillaLab ! biorxiv.org/content/10.1101/… Congrats to @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech and the team! And check out the video by @neeleshsoni03 ! #NPC
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Elizabeth Villa@TheVillaLab
28 Mar 2024
It cannot be done, they said.. It's too flexible, they said.. 😁 biorxiv.org/content/10.1101/… #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf

The Molecular Architecture of the Nuclear Basket

The nuclear pore complex (NPC) is the sole mediator of nucle-ocytoplasmic transport. Despite great advances in understanding its conserved core architecture, the peripheral regions can exhibit...

biorxiv.org
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Ulrich Hohmann@HohmannUlrich
28 Mar 2024
I’m beyond excited to present my postdoc work with @plaschka_lab and @JuliusBrennecke at @IMPvienna @IMBA_Vienna . We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. A thread: 1/x
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Let's go Fred!! Congrats and excited to see you present all the great Arp2/3 work you've been doing.
Fred Erick Fregoso, PhD@FregosoFred
26 Mar 2024
It’s been an arduous road but I got here! Proud to announce that I will be defending my PhD on April 9th! If you’d like to attend virtually, please DM me so I can share the zoom details. Dr. Fregoso coming soon!
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