Kemampuan sel kanker untuk tumbuh dan bertahan hidup tidaklah akibat dari satu perubahan tunggal melainkan hasil dari akumulasi adaptasi biologis yang kompleks. #CancerMechanisms #CancerScience #HallmarksOfCancer #Molecular #Biology

The "Constitution" of Cancer has been rewritten! Douglas Hanahan’s landmark Hallmarks of Cancer 2026 is here, and it’s no longer just about what cancer cells do—it’s about how they organize across four dimensions. We are moving from viewing cancer as a cellular disease to a systemic, multi-dimensional phenomenon. Read the full review in @CellPressNews : 🔗 cell.com/cell/fulltext/S0092… #Oncology #CancerResearch #PrecisionMedicine #HallmarksOfCancer #DouglasHanahan

🧬 Hallmarks of Cancer — Then, Now, and Beyond 📖 Douglas Hanahan @CellPressNews @CellCellPress The cancer biology roadmap just evolved. A landmark update redefining how we understand, study, and treat cancer. 🟢 Key findings 🟢 The original Hallmarks of Cancer framework is expanded to reflect 25 years of progress 🟢 Stronger integration of tumor–host interactions, immune dynamics & microenvironment 🟢 Cancer viewed as a dynamic ecosystem, not a static set of traits 🟢 Direct implications for precision oncology, translational research & trial design 🟢 A unifying language connecting biology → targets → clinical strategy 🟢 Why it matters 🟢 Reframes how resistance, heterogeneity & evolution are interpreted 🟢 Guides next-generation therapeutic combinations 🟢 Essential reading for anyone designing or interpreting modern oncology trials @SamraTurajlic, @KevinLitchfield, @DavidCWedge, @BenWestphalen, @ARosen380 🔗 spkl.io/6010Aqwbi #CancerBiology #HallmarksOfCancer #PrecisionOncology #TranslationalResearch #Oncology #CancerResearch #OncoTwitter

The Hallmarks of Cancer remain oncology's enduring "periodic table", a unifying lens that distills tumor complexity into actionable principles. From the original 6 in 2000, to 10 in 2011, new dimensions in 2022, and now Hanahan's reflective 2025 update ("Then and Now, and Beyond" in Cell), the framework evolves: interconnected networks, spatial niches, eco-evolutionary dynamics, and predictive modeling via AI/spatial omics are the frontier. Monotherapy era? Largely history for advanced disease, hallmark crosstalk demands rational combinations targeting multiple nodes simultaneously. Precision oncology's next era: multi-hallmark disruption for deeper, more durable responses. @EricTopol @Timothee_MD 🔸️ doi.org/10.1016/j.cell.2025.… #HallmarksOfCancer #Oncology #CancerResearch

In this exceptional episode of OncoInfluencers, Prof. @GevTamamyan sits down with one of the greatest scientific minds of our era — Professor Robert A. Weinberg, co-author of The Hallmarks of Cancer, pioneer of oncogene discovery, and a true legend in modern oncology. From the molecular revolution of the 1960s to the birth of oncogenes in 1979, Professor Weinberg reveals how a series of unexpected turns shaped some of the most influential discoveries in cancer research. youtube.com/watch?v=iPVXoXQ0… #Cancer #Medicine #Health #Oncology #OncoDaily #CancerResearch #OncoInfluencers #HallmarksOfCancer #OncologyLeaders #CancerBiology #Oncogenesis #MedX #MedNews #MedEd

🔬 Robert A. Weinberg: The Architect of Modern Cancer Biology From growing up as the child of German Jewish refugees to witnessing the molecular revolution unfold at MIT, Weinberg’s path led him, almost by accident, to one of the most defining breakthroughs in biomedicine: 💡 🧬 the discovery of the first human #oncogene in 1979. He still calls it “the most important thing I ever did in my career.” But his legacy stretches far beyond a single experiment. 📌 He reshaped how we think about #cancer, mentored more than a hundred scientists across the world, and helped build frameworks, like The Hallmarks of Cancer, that became global reference points. And yet, when asked to describe himself in one sentence, he simply said: “A short, stocky, noisy Jew.” But one thing is certain: to generations of scientists, he is anything but small. He is a GIANT. Read the full CancerWorld cover story by @GevTamamyan below 👇 cancerworld.net/robert-a-wei… @oncodaily @MIT @kochinstitute @AACR #CancerResearch #Oncology #CancerBiology #MolecularBiology #BiomedicalResearch #HallmarksOfCancer #MIT #LeadershipInScience #Mentorship #ImmunoOncology #STEM #LifeSciences #Biotech #AcademicLeadership #Inspiration #CancerWorld #OncoDaily

🔴 #INVESTIGACION Una investigación utiliza las características distintivas del cáncer para obtener una nueva perspectiva del crecimiento tumoral. Leer artículo 👉 genotipia.com/genetica_medic…  #geneticamedica #oncogenetica #cancer #tumor #hallmarksofcancer #diamundialcontraelcancer

"The Hallmarks of Predictive Oncology" was published this week with Cancer Discovery @CD_AACR Read here: doi.org/10.1158/2159-8290.CD… #cancerresearch #cancercellmapinitiative #machinelearning #hallmarksofcancer

I often ponder the deep connection between #HallmarksOfAging and #HallmarksOfCancer. This @Nature paper might hold some answers. Paradoxical link between senescent cell state and liver cancer resolved nature.com/articles/d41586-0… #hall_marks_of_aging, #hall_marks_of_cancer

Finally, primary cancers show higher activity in the #HallmarksOfCancer – specifically in “Activating Invasion and Metastasis”, than metastatic cancers. Supports the notion that many primary cancers are being primed for metastasis before they leave the tissue of origin! 🧵8/10

What a great start for the Norwegian Cancer Symposium by Prof. Douglas Hanahan @EPFL ! #HallmarksofCancer We are also celebrating the 70th anniversary of our Institute for Cancer Research at The Norwegian Radium Hospital 🥳🎉🇳🇴🇳🇴🇳🇴@Oslounivsykehus!

#Hallmarksofcancer cookie wars: #Immunecheckpoint inhibition

#Hallmarksofcancer cookie wars: #Immuneevasion

Next round of #hallmarksofcancer food: #Invasiveness and #Metastasis of jelly #cancer cells in a puff pastry cake 🥞.

You know about the #HallmarksOfCancer, but do you know about the #HallmarksOfPrecancer? Read @kenlaulab's latest paper published in @CD_AACR in which he and collaborators describe the principles governing the biology of early lesions. #AACR24 medschool.vanderbilt.edu/bas…

In our recent article we assigned genomic alterations to each hallmark and uncovered some intriguing patterns - Elie G. Dib @WeAreTandF #Cancer #CancerBiology #CancerGenomics #CancerTherapies #HallmarksOfCancer #OncoDaily #Oncology #PrecisionMedicine oncodaily.com/46980.html

A must read issue of @CD_AACR with super important commentaries on #HallmarksOfCancer

'Hallmarks of Cancer' paper gets an upgrade to v 3.0 in this issue of Cell - @DrHBurstein @CellCellPress #CancerCell #CellJournal #HallmarksOfCancer #OncoDaily #Oncology oncodaily.com/43487.html

My class of technicians visualizing the #hallmarksofcancer. Self-sustained growth signaling and resistance against growth inhibition: A delicious cake in the shape of a petridish with overgrowing #cancer cells... @LMU_RadOnc, #radiationbiology

💫🌟🔝🔝🔝🔍Fantastic article!  One of the most anticipated!   💫🌟New Insights into Cancer Biology: Hallmarks of Cancer: New Dimensions by Dr Douglas Hanahan!!🌟💫📚💎 @epflSV 📝 Abstract Overview: 🔸️ The article presents an enhanced understanding of cancer's complexity, proposing new dimensions to the existing hallmarks of cancer framework. 🔸️ These new aspects include phenotypic plasticity, nonmutational epigenetic reprogramming, polymorphic microbiomes, and the role of senescent cells in the tumor microenvironment. 🔬 Introduction and Background: 🔸️ Initial hallmarks of cancer identified crucial capabilities in cancer cells for malignant tumor formation. 🔸️ The original six hallmarks were later expanded to eight, encapsulating core cancer behaviors. 🔸️ The article emphasizes the importance of refining and expanding the hallmarks concept with emerging scientific evidence. 🌟 Key Findings and Messages: 1️⃣ Unlocking Phenotypic Plasticity:    🔸️ Proposed as a new hallmark, it describes how cancer cells evade terminal differentiation to maintain or regain proliferative capacity.    🔸️ Examples include dedifferentiation in colon cancer and melanoma, and blocked differentiation in leukemias. 2️⃣ Nonmutational Epigenetic Reprogramming:    🔸️ Suggested as an enabling characteristic, separate from genetic mutations.    🔸️ Epigenetic changes influence gene expression and cancer hallmarks without altering the DNA sequence.    🔸️ Influences include microenvironmental factors like hypoxia and nutrient deprivation. 3️⃣ Polymorphic Microbiomes:    🔸️ Emerging evidence suggests microbiomes, especially in the gut, play a critical role in cancer development and response to therapy.    🔸️ Microbiomes may affect cancer by modulating the immune response and inducing genetic mutations in host cells.    🔸️ They might serve as enabling characteristics, influencing the acquisition of cancer hallmarks. 4️⃣ Senescent Cells in the Tumor Microenvironment:    🔸️ Senescent cells, once thought to suppress tumorigenesis, may actually promote cancer under certain conditions.    🔸️ They can influence tumor progression through their senescence-associated secretory phenotype (SASP).    🔸️ Senescent cells in the tumor microenvironment contribute to various cancer hallmarks, including promoting inflammation and altering immune responses. 🔚 Concluding Remarks: 🔷️ The article encourages ongoing discussion and investigation in the cancer research community. 🔷️ These new dimensions could refine cancer treatment strategies and our understanding of cancer biology. @OncoAlert @OncoReporte 🔗 #HallmarksOfCancer #CancerBiology #Hanahan #OncologyResearch #ScientificAdvances #MedicalBreakthroughs aacrjournals.org/cancerdisco…