Researchers at Sylvester have discovered a way to turn resistance against cancer cells. Their findings are published in Genes & Development (
@GenesDev).
The new study uncovers how blocking a key protein, p300, forces damaged cancer cells into a state of uncontrolled transcriptional activity. This creates a novel form of cellular stress that can make chemo-resistant tumors sensitive again to treatment. When combined with platinum chemotherapy, the two treatments worked synergistically, selectively eliminating tumor cells and restoring chemotherapy sensitivity. Learn more:
loom.ly/OZSsRbs.