Joined January 2020
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94 Photos and videos
Inga Songailiene retweeted
Genome delivery of a contractile tailed phage and its superinfection exclusion mechanism | bioRxiv biorxiv.org/content/10.64898…
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Toprim is different domain than HEPN. MNT can fit in here.
tRNA cleavage expriments from our MNT-HEPN study really helped for Eco2. The study:
pubmed.ncbi.nlm.nih.gov/3329…
nature.com/articles/s41594-0…
Retron Eco2, another derivative of TA system HEPN-MntA (doi: 10.1093/nar/gkaa855), works as a trimeric complex that is activated by T2 phage endonuclease DenB, which cleaves msDNA & leads to RNA degradation.
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Jan 28
Deoxydinucleotides can activate doughnut-shaped mutimeric HEPN ApeA nucleases for tRNA cleavage in the anticodon loop ✂️🛡🧬
Great work lead by Jonas, Giedrius and great team 💪🙌
🧬 We discovered how bacteria detect phage infections by sensing fragments of their own degraded DNA.
Meet #ApeA – a #BacterialImmunity system activated by a novel signal - #Deoxydinucleotides.
Read our preprint: biorxiv.org/content/10.64898…
A thread 🧵 (1/11)
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Inga Songailiene retweeted
23 Oct 2025
Happy to share that our paper on the PlPVC1 eCIS is out in @NatureComms 🥳 Congratulations to first author Leyre Marín-Arraiza and all co-authors! #cryoEM @cryoEM_Papers @UCPH_CPR nature.com/articles/s41467-0…
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11 Jul 2025
Impressive work!
10 Jul 2025
biorxiv.org/content/10.1101/…
New type IX toxin/antitoxin system, anti-phage system Clover, where antitoxin produces 5′-triphosphothymidyl-3′5′-thymidine to inhibit the dGTPase toxin.
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13 Jun 2025
Impressive spacer selection mechanism by Cas9-adaptation supercomplexes - all pathway captured by #cryoEM #Cas9 🧬🧩🧵
13 Jun 2025
'Structural insights into Cas9-mediated prespacer selection in CRISPR-Cas adaptation'
Check out our preprint on #bioRxiv on the #Cas9-Cas1-Cas2-Csn2 supercomplex involved in #CRISPR spacer acquisition: biorxiv.org/cgi/content/shor…
Thread below.
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Inga Songailiene retweeted
10 Jun 2025
Excited to see our work published in @ScienceAdvances!
We present RBPseg, a method for structural prediction of #phage receptor-binding proteins.
We applied it to diverse tail fibers and validated the predicted structures using #cryoEM.
Read here: science.org/doi/10.1126/scia…
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Inga Songailiene retweeted
25 Mar 2025
I highly recommend attending this amazing microbiology conference!
🦠🔬👩🏼🔬🧬🧪
Only a few more days to submit your abstracts! (April 1st ).
Looking forwards! 🍻
25 Mar 2025
⏳ The #EESMicrobiology abstract submission deadline is fast approaching ⏳
🦠🔬 Don't miss the chance to present your research to top scientists from around the world working with bacteria and new technologies!
Submit your abstract by 1 April 👉 s.embl.org/ees25-06-x
This EMBO | EMBL Symposium will focus on new approaches and technologies that have the potential to revolutionise future microbiology research, from systems-based to single-cell 🧬
📅 24 – 26 June
📍 EMBL Heidelberg and Virtual
#EMBLEvents #Microbiology
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Inga Songailiene retweeted
18 Feb 2025
RNA-guided systems span kingdoms, from bacterial immunity to eukaryotic gene regulation. How did they evolve? We traced the origins of CRISPR-Cas13 and identified its likely ancestor: an RNA-based toxin-antitoxin (TA) system. Here’s what we uncovered:
cell.com/cell/fulltext/S0092…
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Inga Songailiene retweeted
6 Jan 2025
Looking forward to this.
gmc.vu.lt/en/events-and-invi…
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29 Dec 2024
I can add "Life's Engines: How Microbes Made Earth Habitable" by Paul G. Falkowski.
What more can you recommend for next year?
28 Dec 2024
My favorite books, 2024
by @emollick @firstadopter @anilananth @harari_yuval @carlzimmer and other great authors not on X
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Inga Songailiene retweeted
22 Nov 2024
Happy to share our spotlight (with @g1_guillermo at @UCPH_CPR) in @CellChemBiol, highlighting the groundbreaking work by @IlyaOsterman & @SorekLab on how #phages reconstitute NAD to bypass bacterial immunity🦠🛡️. Check it out here! rb.gy/n8w9na 🤓
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Inga Songailiene retweeted
22 Dec 2024
Excited to share our latest collab with Wenyuan Han's Lab! 🚨 Bacteria use dITP as an immune signal to activate NAD -depleting effectors. Phages counter immunity by destroying dAMP (dITP precursor)! 💥🧬
Preprint 🔗: biorxiv.org/content/10.1101/…
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Thrilled to share that our Zorya paper is now published online in Nature! It was an incredible team effort @__jphilipp @Salmo_Lab @SimonJacksonNZ —thank you to everyone who contributed to this work.@IngaTrails @VKleinSousa @AritzRoa @freddie__martin @yongwangKU @AHarms485 @others
11 Dec 2024
Very happy our paper on Zorya anti-phage defense system is now published in
@Nature! 🥳 Big congrats to first authors
@HaidaiHu and @__jphilipp and all other authors! Wonderful collab with @Salmo_Lab
and @SimonJacksonNZ #cryoEM @UCPH_CPR @koebenhavns_uni nature.com/articles/s41586-0…
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Inga Songailiene retweeted
30 Nov 2024
Our laboratory is looking for a postdoc with expertise in protein biochemistry and structural biology to work on novel pathways regulated by ADP-ribosylation of nucleic acids. Please RT.
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Inga Songailiene retweeted
14 Nov 2024
We cracked the tRNA specificity of FaRel2 toxSAS. A fun collaboration with the @SuzukiRNALab, Garcia-Pino @gem__atkinson and Polikanov. Out in @ScienceAdvances! science.org/doi/10.1126/scia…
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Inga Songailiene retweeted
22 Nov 2024
Would you prefer to lead a lab alone or together with a science buddy? How interesting would be a research institute where joint labs are the standard?!
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17 Nov 2024
Congrats Andriana and Cas for such a nice work!
Nice to see one system dedicated to Lithuanian 🇱🇹 god for fermentation, bread and beer production - Rugutis or Rūgutis! 💚🤟
11 Aug 2024
My first first-author publication on the discovery of antiphage systems in the lactococcal plasmidome, out in @NAR_Open!
Huge thanks to my PhD supervisors @VanSinderenLab and @JenniferMahony7 and all the collaborators.
See comments for a quick summary!
doi.org/10.1093/nar/gkae671
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Inga Songailiene retweeted
13 Nov 2024
Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥
Thrilled to present part 2 of my postdoctoral work with @NogalesLab @CollinsRNPLab @berkeleyMCB where we investigate this using #CryoEM and transgene insertion in 🧪 and cells!
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