🧬 CANCER TREATMENTS ACCELERATE AGING — BUT EXERCISE SLOWS IT DOWN
Modern cancer therapies save lives — but they can also age the body faster.
According to Nature Reviews Cancer (Demaria, 2025), treatments like chemotherapy, radiation, and immunotherapy can damage DNA, accelerate cellular senescence, weaken the immune system, and promote frailty, fatigue, and cognitive decline — hallmarks of premature aging.
💡 Here’s the good news:
Exercise acts as precision anti-aging medicine.
It enhances DNA repair, boosts mitochondrial function, clears “zombie” senescent cells, and reduces inflammation.
It protects the heart, strengthens muscle and bone, sharpens the brain, and restores immune function — reversing many of the biological effects that cancer therapy leaves behind.
This is where Clinical Exercise Physiologists play a vital role — translating research into individualized programs that rebuild vitality and resilience across the cancer care continuum.
The goal is no longer just survival — it’s healthy longevity after cancer.
Demaria, M. Cancer treatments accelerate ageing. Nat Rev Cancer 25, 751–752 (2025).
doi.org/10.1038/s41568-025-0…
nature.com/articles/s41568-0…
Supportive Research on the Role of Exercise:
1) An KY, Min J, Lee DH, Kang DW, Courneya KS, Jeon JY. Exercise Across the Phases of Cancer Survivorship: A Narrative Review. Yonsei Med J. 2024;65(6):315-323. doi:10.3349/ymj.2023.0638
2) Campbell KL, Winters-Stone KM, Wiskemann J, et al. Exercise Guidelines for Cancer Survivors: Consensus Statement from International Multidisciplinary Roundtable. Med Sci Sports Exerc. 2019;51(11):2375-2390. doi:10.1249/MSS.0000000000002116
3) Jiang Y, Ghias K, Gupta S, Gupta A. MicroRNAs as Potential Biomarkers for Exercise-Based Cancer Rehabilitation in Cancer Survivors. Life. 2021; 11(12):1439.
doi.org/10.3390/life11121439
4) Bettariga F, Taaffe DR, Borsati A, et al. Effects of exercise on inflammation in female survivors of nonmetastatic breast cancer: a systematic review and meta-analysis. J Natl Cancer Inst. 2025;117(10):1984-1998. doi:10.1093/jnci/djaf062
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