Excited to share our latest study in @NatureComms where we uncover a new mechanism of chromatin regulation that is essential in certain SWI/SNF-mutant cancers. Congrats to @HaydenMalone3 and coauthors! #SWISNF #cancer (1/8) @stjuderesearch @stjudegraduate nature.com/articles/s41467-0…

🌟A new actionable vulnerability in prostate cancer🌟 🆕️🎓A double-negative prostate cancer (DNPC) subtype, lacking AR and neuroendocrine signaling, shows selective vulnerability to SWI/SNF-targeting degrader molecules. doi.org/10.1158/0008-5472.CA… @OncoAlert Key findings 🔍 ▪️ DNPC displays dependency on SWI/SNF chromatin remodeling complexes ▪️ Targeted degraders induce tumor-selective lethality ▪️ Epigenetic rewiring → loss of lineage plasticity survival advantage ▪️ Opens a therapeutic window for an otherwise treatment-refractory subtype Why this matters 🎯 This work provides a biologically grounded strategy for precision targeting of aggressive AR-independent prostate cancer—moving beyond hormonal paradigms. @AACR @UroDocAsh @ASCO @myESMO @APCCC_Lugano @neerajaiims 👏 Outstanding work by Mark A. Rubin and colleagues #ProstateCancer #PrecisionOncology #Epigenetics #SWISNF #CancerResearch #TranslationalScience #DNPC #AACR

Dual loss of #SMARCA2 #SMARCA4 is rare. PhD candidate @field_natisha in our gp leads an insightful review in #CancerLetters on disparate malignancies with this loss that impacts on #ChromatinRemodeling. #SWISNF #OvarianCancer #LungCancer. Read here: 10.1016/j.canlet.2024.217282

Our new paper deep dives into genetic & epigenetic changes in members of a chromatin remodelling complex in #ovariancancer & #endometriosis. Molecular events reveal new therapeutic options for challenging conditions. #SWISNF mdpi.com/2941244 #mdpicancers via @Cancers_MDPI

🚨Pre-print alert!!🚨 Thrilled to share my postdoc work in the @bernstein_lab @IcahnMountSinai, where we dove into the differences between #swisnf complexes and found an unappreciated role for PBAF at repressive chromatin biorxiv.org/content/10.1101/… (1/3)

🚨 New Research Alert! 🚨 Excited to share our latest paper on PHF6's role in linking H3K14 acetylation, #SWISNF, and #RNApolymerase complexes. Now live in @NatureComms! 🎉 Big congrats to the first author, @priya1012007, and all co-authors! 👏 nature.com/articles/s41467-0…

In this work we investigated the role of the canonical BAF complex (a.k.a. SWI/SNF @swisnf) in generation of humoral immune responses. We discovered that the Arid1a-dependent BAF complex is indispensable for production of high-quality antibodies in the germinal centers 2/n

Our comment on aberrant, weak or moderate BRG1 (SMARCA4) expression in SCCOHT. This IHC pattern is abnormal, and consistent with SMARCA4 gene alterations and with SCCOHT. Have you seen it in your practice? @GynPath #PathTwitter #pathology @swisnf journals.lww.com/ajsp/fullte…

Excited to share our new review in @NatRevDrugDisc covering ongoing efforts to therapeutically target chromatin remodelers focusing on SWI/SNF complexes. Congratulations to authors @HaydenMalone3 and Charlie! @stjudegraduate @stjuderesearch #swisnf (1/9) nature.com/articles/s41573-0…

Happy that one of these is ours - "FDA-approved therapeutic compound library screen to discover new drugs to treat ARID1A mutant ovarian cancer" working with the ANU Centre for Therapeutic Discovery @ANU_Therapeutic #DrugLibraryScreening #ARID1A #SWISNF #ovarianclearcellcancer

Congratulations to the Bartholomew lab @BlaineBartholo2 and especially to DJ @DhurjhotiS for leading this amazing work!! @SRINIVASANIMIR1 JunwooLee AnnaThommen YueLu McKenzie Murvin Mauro Calabrese @MolecularCell @MDAndersonNews #SwiSnf #AThook #Brg1 #epigenetics #EMC

Congratulations to @FreddyMValencia and @akshaysci on their newest study, just published in @NatureGenet ! Beautiful analysis highlighting that #SWISNF /#BAFcomplex genes are the most frequently perturbed gene classes in #neurodevelopmental disorders. nature.com/articles/s41588-0…

Check out this Research Highlight about our latest work in @Nature describing a role for #SWISNF in mitotic bookmarking

Excited to share our latest work #SWISNF in #DIPG from star postdoc Mateus from an amazing collaboration with @ArulChinnaiyan, @abhijitparolia and many others. Thanks @chadtough for supporting our work! @tamcarr21 @AFriedholm @UMRogelCancer @UMichPath pnas.org/doi/10.1073/pnas.22…

These findings are exciting to us since they have broader implications in the context of protein co-assembly mediated via intrinsically disordered domains and gene regulation. #BAF #SWISNF #chromatin #condensates #prion #IDPs @FNucleosome

Study reveals #epigenetic vulnerability of #acuteMyeloidLeukemia @hodgeshc @CourtneyCEC @RachelRau3 et al @CureCancerNow @bcmhouston @TheVFoundation @CR_AACR @BCMCancerCenter @bcmhouston @BCMGradSchool @SWISNF #PU1 medicalxpress.com/news/2023-… via @medical_xpress

Dr. H.C. Hodges @hodgeshc, C Chambers @CourtneyCEC, Drs. @RachelRau3, K Cermakova @katacermaku et al reveal an #epigenetic vulnerability of #acuteMyeloidLeukemia @CR_AACR @BCMCancerCenter @bcmhouston @BCMGradSchool #SWISNF #PU1 bcm.edu/news/study-reveals-e…

From the December issue: Epigenome Programing by H3.3K27M Mutation Creates a Dependence of #PediatricGlioma on #SMARCA4, by Mo et al. bit.ly/3hXWV5I @ColumbiaGenDev @ColumbiaMed #Epigenetics #SWISNF

From the December issue: BAF Complex Maintains #Glioma Stem Cells in Pediatric H3K27M Glioma, by @Eshini_Pandit, Joana Marques, @JunQiLab, @FilbinMariella et al. bit.ly/3Gafi0l @DanaFarber #Epigenetics #SWISNF

Thank you Marco! That is really interesting. All this further supports that AP-1 cannot open chromatin by itself, but rather bind dense chromatin and recruit a remodeller to open chromatin. @GabriellaFicz