Engineered extracellular vesicles reprogram T cells in inflammatory bowel disease, demonstrating the therapeutic potential of precision immune modulation and cell-targeted delivery. doi.org/10.1038/s41392-025-0… #ExtracellularVesicles #TCells #InflammatoryBowelDisease #ImmuneModulation #CellEngineering #PrecisionMedicine

Stoked that the project I started as soon as I started my PhD with @tfadgreef is finally out on #bioRxiv! 📜 Huge effort. 💪🏼It took a village to raise that baby! 👶 🥰 I came in knowing nothing about synthetic receptors (my background was #microRNAs). Tom’s idea to add a miRNA negative feedback loop to #synNotch -the way nature does it-finally became reality with my amazing co-first authors Bryan Nathalia 🦸 and Tom Meuleman 👨‍🔬. We built a self-limiting, tunable system where activated synNotch induces its own repressor and autonomously attenuates signaling over time. Really excited about the bigger picture here: embedding this kind of autonomous control has the potential to make engineered cells more predictable, tunable, and adaptive — exactly what we’ll need for safer, smarter cell therapies. Huge thanks to Bryan, Tom, and the whole team at TU/e, Utrecht University & MIT. Preprint 👉 lnkd.in/eWZWh937 #SyntheticBiology #CellEngineering #synNotch

Do you want to advance your skills in genome editing and cell engineering? 🧬✂️ Apply today for the comprehensive #EMBLCRISPRcas course that offers hands-on training in designing CRISPR targets, generating gene knock-outs/knock-ins, and validating targets using cutting-edge technologies. 👉🏻 s.embl.org/gee26-01-x Tailored for both mammalian cells and mouse embryos, the course is divided into two specialised groups based on participants' expertise. No previous experience in genome editing is required. The modules include: 🧬 How to create a CRISPR/Cas9 experiment using various design tools 🧬 Transfection optimisation for efficient gene editing 🧬 Generation of knock-out and knock-in cell lines and mouse embryos 🧬 Validation of genome-edited cell lines and embryos 🗺️ EMBL Heidelberg 📅 6 – 11 September 📥 Apply by 31 May 2026 #EMBLEvents #EMBL #lifesciencetraining #lifesciences #molecularbiology #genome #CRISPR #geneediting #gRNA #Cas9 #genomeediting #cellengineering #ScienceEducation

🚨 Postdoc opening @MIT Galloway, Voigt & Birnbaum Labs are hiring to engineer human cells and tackle challenges in immune cell engineering. 👉 PhD eukaryotic cell engineering experience required. Details below. #SynBio #Postdoc #CellEngineering @Geneticdesigner @MEBirnbaum @kochinstitute @MITChemE

💥Check out the publications from Peking University in 2024-25 🏫@PKU1898 📌#Biomechanics #WoundHealing #BreastCancerResearch #ImageAnalysis #CellEngineering #Biosensors #MachineLearning

💥Check out the Third Edition of our Title Story Collection from 2024 📌 #Organoids #ReproductiveBioengineering #3DPrinting #Bioinks #CancerTheranostics #MedicalImaging #Mammography #AutomationInBiology #CellEngineering #TissueEngineering #Neuroimaging #MEGEEG

💥Check out the Second Edition of our Editor's Choice Papers from 2025 📌 #MachineLearning #PrecisionMedicine #Ophthalmology #Orthopedics #CorneaResearch #ProteinLigand #DeepLearning #PolypSegmentation #Biomechanics #SyntheticBiology #CellEngineering

💥Check out the Third Edition of our Title Story Collection from 2024 📌 #Organoids #ReproductiveBioengineering #3DPrinting #Bioinks #CancerTheranostics #MedicalImaging #Mammography #AutomationInBiology #CellEngineering #TissueEngineering #Neuroimaging #MEGEEG

Dr. @AnnaBlakney’s team at @ubcmsl received $8.4 million USD to support their work revolutionizing cell therapy manufacturing and delivery methods! 🎊 This grant that will allow them to further explore and develop a delivery platform for immune #CellEngineering. Congratulations! bit.ly/4pLRjbm

STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion 1. Researchers have developed STAMPS, a novel AI-driven method to design synthetic signal peptides that enhance protein secretion in mammalian cells. This work represents a significant leap in optimizing bioproduction and cell engineering applications. 2. The study leverages a fine-tuned autoregressive transformer model trained on over 6,000 mammalian signal peptides. The model generates de novo sequences that outperform traditional signal peptides like IgKL, achieving up to 2.3-fold increases in protein secretion. 3. A key innovation is the model's ability to identify sequence features driving high secretion, such as a long hydrophobic core and tightly positioned cleavage sites. This provides valuable insights into the sequence-function relationship in signal peptides. 4. The practical applicability of STAMPS is demonstrated through high-throughput screening in both HEK293T and CHO cells, highlighting its transferability across different mammalian hosts. This versatility is crucial for industrial biomanufacturing. 5. The study also shows that synthetic signal peptides can significantly boost the secretion of therapeutic proteins like VHH-Fc, confirming their potential for improving bioprocess yields in industrial settings. 📜Paper: biorxiv.org/content/10.1101/… #STAMPS #ProteinSecretion #AIinBiology #Bioproduction #CellEngineering

Black Friday Week for CellEDIT 🖤 Order 2 custom CRISPR cell lines, get 1 FREE (3 for 2).🖤 🖤 🖤 • Vector-free direct intranuclear delivery (FluidFM) • Works on hard-to-transfect cells • Reduced off-targets, precise QC • Use cases: Point mutations, small KIs, tagging, multiplex KOs To redeem, connect with our Sales Manager, Dr. Gorka Santos, by Cyber Monday, 11:59 PM PT (PST) 👉 bit.ly/43MKm13 #BlackFriday #BlackFridayWeek 🛒💸💰#GeneEditing #CRISPR #CRISPRCas9 #GenomeEngineering #GeneticModification #PrecisionGeneEditing #FunctionalGenomics #GeneTherapy #CellEDIT #SingleCellEngineering #PrecisionCRISPR #NextGenGeneEditing #CellEngineering #CustomCellLines #CellLineDevelopment #CellManipulation #GeneticallyEngineeredCells #SyntheticBiology

The late-breaking abstract deadline has been extended to December 17 to support those impacted by the government shutdown. Submit here: bmes.org/2026/cmbeconference… #CMBE2026 #Bioengineering #CellEngineering #MolecularEngineering

#Neutrophils as tiny doctors? Targeted nanoparticle delivery opens a new era of #Nanomedicine and #CellEngineering where cells act with our will. Check👉sj.jst.go.jp/interviewsandop…　#APRC　#ScienceJapan　#Moonshot

DNA → RNA → Amino Acids → Proteins → Cells → Human. These are the fundamental building blocks of the human body. Each new Kaggle competition gives me a different perspective on AI models by working on RNA 3D structure prediction, measuring the impact of gene silencing in cells, predicting protein functions using amino acid sequences. #cellengineering

Computationally Designed Receptors Help Engineered T Cells Control Tumors Study sets stage for development of synthetic #biosensors with custom-built sensing and responses for basic and translational #cellengineering applications @EPFL_en #Tcells #tumors hubs.li/Q03QLJZX0

Summer break is over, but your CellEDIT-ed cells came back healthy, happy, and multiplexed — just the way you wanted. 🧬✨ While some cells return from vacation with nothing more than a sketchy nose job 👃😬 #CellEDIT delivers the full makeover: Vector-free, intra-nuclear delivery with precise RNP stoichiometry and multiplex genome editing — for results that are accurate, safe, and seriously impressive. 💅🧬 #CellGlowUp #BackToSchool #MultiplexEditing #SingleCellEngineering #PrecisionCRISPR #NextGenGeneEditing #CellEngineering #CustomCellLines #CellLineDevelopment #CellManipulation #GeneticallyEngineeredCells #SyntheticBiology

From inspiring talks to cutting-edge research, it is amazing connecting with those shaping the future of biotech at Genome Engineering: CRISPR Frontiers at @CSHL! Stop by our booth if you haven’t had the chance to yet! 🧬🧫 #CRISPR #CSHL #CellEngineering

Biomaterial scaffolds for therapeutic immune cell engineering and delivery. | Quanyin Hu @BadgerPharmacy | [50 days' free access] #CellDelivery #CellEngineering #scaffold kwnsfk27.r.eu-west-1.awstrac…

Introducing Cell Therapy & Engineering Connect — a new open-access, peer-reviewed journal at the forefront of cell engineering, gene editing, stem cell tech, tissue engineering, and more! 📘 Print & online 📅 Biannual 💸 No publication fee until Dec 2025 🌐 Open Access for all! Submit now & join the next wave of bioinnovation. scifiniti.com/journals/cell-… #CellTherapyEngineeringConnect #Scifiniti #Cellengineering #geneediting #stemcell #tissueengineering #regenerativemedicine

Integra Therapeutics is ready for #BIO2025 in Boston! Explore how we are leading the next generation of #CellEngineering technology and #CellTherapy products. Meet our CEO @avenciasm at BIO Partnering™: convention.bio.org/partner With @ICEX_ and @AseBio