Recently published: #CellState Transitions Drive the Evolution of Disease Progression in B-Lymphoblastic Leukemia, by Ling Zhang, Jeffrey West, and colleagues doi.org/10.1158/2767-9764.CR… @mathoncbro @S_Marzban @nancykgillis @bshah @MoffittNews #BcellALL #OpenAccess

It has been wonderful to collaborate with so many brilliant colleagues and friends @andygxzeng, Qingsong Gao Laura Garcia-Prat, John Dick @CMullighan and many others @StJude @StJudeResearch @UHN_Research #leukemiaresearch #singlecells #cellstate

How real do you want it to be? // CellCore.ts@CellularDecorator({ integrity: 'maximum', metabolism: 'optimized' }) export class CellCore { private static instance: CellCore; private metabolicState: MetabolicState; private energyLevel: number; constructor() { this.metabolicState = new MetabolicState({ atp: 'high', homeostasis: 'balanced', ph: 7.4 }); this.energyLevel = 100; } public initializeCycle(): void { this.metabolicState.activate(); this.monitorHomeostasis(); this.maintainIntegrity(); } } // MetabolicDashboard.tsx ```typescript export const MetabolicDashboard: React.FC = () => { const [cellState, setCellState] = useState<CellularState>(); const [temperature, setTemperature] = useState<number>(37); const [oxygenLevel, setOxygenLevel] = useState<number>(100); useEffect(() => { const core = CellCore.getInstance(); core.state$.subscribe(state => { setCellState(state); monitorVitals(state); }); }, []); return ( <div className="cellular-dashboard"> <CellVisualizer state={cellState} /> <MetabolicMonitor temp={temperature} o2={oxygenLevel} /> <MitochondrialStatus /> </div> ); }; // MembraneControl.ts ```typescript export class MembraneControl { private transport: TransportSystem; private signals: Map<string, Signal>; constructor() { this.transport = new TransportSystem({ selectivity: 0.99, permeability: 'controlled', integrity: 'maximum' }); this.signals = new Map(); } public async processSignal(signal: CellSignal): Promise<void> { const response = await this.transport.process(signal); this.monitorResponse(response); this.maintainHomeostasis(); } }

@Lo_Zanzi @OstuniLab @lai9uan #nomenclature #cellstate

It was truly a pleasure to speak on #AI for #Innovation, #Genomics, and #Medicine at our @MIT #IAP class with @RickardGabriels on #FoundationModels and #GenerativeAI. So many extraordinary advances to cover, each more exciting than the other. Video here: youtube.com/watch?v=pHzdw6YW… Topics touched upon: - #CNNs for #RegulatoryGenomics and #MutationEffect prediction - #GNNs for #DrugDevelopment - #Transformers for #ProteinFolding - #VAEs for #SingleCell expression - #CLIP for #MedicalImaging-#Legends - #MultiModal function-sequence-structure for #TherapeuticDesign - #CognitiveSpace navigation for #patients #EHR, #ProteinFunction, #CellState, #DrugEffects, #ScientificPapers, #Grants, #Patents, #Education, #Investment, #Discovery, #Management, #Productivity, and #Innovation. Some slides attached below, lots more coming! :-)

Day 3 of #IBS2023 began with an exciting plenary session on "#Physical #Principles in #Development". Chaired by @KobeScienceBoy, it featured talks by: - #GVShivashankar - @bdpmax - #HiroshiHamada #Mechanogenomics #CellState #fluidity #rheology #tissue #symmetry #vertebrates

🚨New Article🚨 “Using quantitative methods to understand leaf epidermal development" By Chi Kuan et al. @KuanChi_ 👉cambridge.org/core/journals/… #leafepidermaldevelopment #quantitativemethods #SLGC #stomata #cellstate @yang_soli @KimmyHo7 @AcademiaSinica @IPMBSinica

New research in Neuro-Oncology finds that a novel #radiation therapy schedule based on mathematical modeling of #cellstate plasticity is feasible and safe to administer to #glioblastoma patients. academic.oup.com/neuro-oncol…

On this week's episode: an alternate #TCACycle! 🔄 @MSKCancerCenter researchers identified a non-canonical TCA cycle that is required for changes in #CellState. #KrebsCycle @paigearnold2 @__btjackson @lydfinley 📎 go.nature.com/3KuTnAs 🎙️ bit.ly/3NdnSgs

A new twist on an 80-year-old biochemical pathway? 🔀 Dr. @LydFinley's team at @MSKCancerCenter, led by @PaigeArnold2 and Benjamin Jackson (@__btjackson), identified a non-canonical #TCACycle that was required for changes in #CellState. 📝 @Nature | go.nature.com/3KuTnAs

$100K from the SBA Administration infused into Tucson Innovation Ecosystem. UACI & Startup Tucson secured two Growth Accelerator Fund Competition prize awards. Info here: bit.ly/3u6BHUH Nikita Fernandes, Research Scientist at Cellstate Biosciences, pictured below.

Elsa Sanchez-Garcia is offering a #postdocjob to work on the #computationaldesign of #chemicaltools and #inhibitors for the study of proteins and #proteinproteininteraction|s involved in #cellstate transitions ➡️uni-due.de/crc1430/open-posi… #computationalbiochemistry

Today @KojinTx launched with a $60M Series A. I’m excited to be joining the company’s board of directors as we create transformative medicines through groundbreaking #CellState and #Ferroptosis biology. businesswire.com/news/home/2… @CathayCapital

Founded by leading scientists @SchreiberStuart, Ben Cravatt, Stephanie Dougan and @VasanthiViswa, we are harnessing the power of #Ferroptosis and #CellState biology to selectively target disease-associated cells and unlock enormous potential for #DrugDiscovery.

Kojin Therapeutics is here! We’re excited to announce our $60M Series A to accelerate our #DrugDiscovery platform and develop a new category of #therapeutics based on #CellState and #Ferroptosis biology. bwnews.pr/3pyBKGK

Excited to share the stage of the @AMIAinformatics Virtual Conference May 20th at 11:30am EDT with @DoDJAIC @doctortetteh & Lt. Cmdr Peter Walker, Ph.D. & @Humetrix CMO @CellState. We will highlight the power of the DoD JAIC Project Salus platform to monitor the #COVID19 pandemic

#LineageTracing on #TranscriptionalLandscapes | links #CellState to #CellFate during Differentiation | Allon Klein @harvardmed @sciencemagazine buff.ly/34Sce6b | #2020_Jan_ReCap

Nice questions indeed...do we only know that we know nothing? @ozsinglecells #cellidentity #cellstate #cellstate

Now @dana_peer on about recent work by @SettyM, & work expanding on #RNAvelocity with CellRank: Markov modeling the propagation of velocities across #CellState manifold. This improves certainty about eventual fates when states overlap. Applying to lung cancer dedifferentiation.

Next up in my curated list of #innovative #scicomm is a beautiful analogy by @denisjabaudon to explain a #biological concept (#CellState being determined by #GeneNetworks) using a #physical system (a pendulum & some magnets)! #devbio #development #scivid x.com/denisjabaudon/status/1…